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Revista Cubana de Farmacia
versão On-line ISSN 1561-2988
Resumo
GRA RIOS, Gisela; FERNANDEZ MONAGAS, Sol Amalia; CASTINEIRA DIAZ, Mirta e BARRIOS ALVAREZ, María Aurora. Validación de los métodos analíticos empleados en el estudio del inyectable de fosfato de disopiramida (13 mg/mL). Rev Cubana Farm [online]. 2003, vol.37, n.2, pp. 0-0. ISSN 1561-2988.
The validation of an spectrophotometric method, which will be used in the quality control of injectable disopyramide phosphate (13 mg/mL), was made in which absorbance was estimated at 269 nm and the dissolvent used was a sulfuric methanol mix. Also, the validation of a high performance liquid chromatography technique was carried out in which a Lichrosorb RP-8 column, and a solution of monobasic sodium phosphate (0,05 mol/L) ph3: acetonitrile (73:27 v/v) as mobile phase were employed. Both methods turned out to be linear, precise and accurate, within the range of concentrations already studied. Also, this paper proved the specificity of high performance liquid chromatography technique.
Palavras-chave : DISOPYRAMIDE; SPECTROPHOTOMETRY; QUALTY CONTROL.