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vol.42 número1Validación de la técnica de determinación del nitrógeno amínico al trofin en su forma líquidaValidación del ensayo de disolución de las tabletas de propiltiuracilo 50 mg índice de autoresíndice de assuntospesquisa de artigos
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Revista Cubana de Farmacia

versão On-line ISSN 1561-2988

Resumo

DIAZ POLANCO, Iverlis et al. Development of a formulation of coated secnidazole tablets 500 mg. Rev Cubana Farm [online]. 2008, vol.42, n.1, pp. 0-0. ISSN 1561-2988.

The development of a formulation of coated Secnidazole tablets 500mg was described. During its development, 2 methods were evaluated: dry granulation and humid granulation. A hydroalcoholic system was used with the Policoat YS 1-7003 (Opadry)® commercial preparation for coating the tablets. The batches subjected to stability assays were made at pilot scale by humid granulation, which showed the feasibility of the manufacturing process at this scale. The coated tablets had adequate physicomechanical and technological properties and they were packed in polyethylene flasks of high density and in polyvinyl chloride/aluminium thermoconformed envelopes. The chemical and microbiological stability of the secnidazole tablets were studied during 24 months. The results demonstrated that these tablets met the requirements established during this period

Palavras-chave : Secnidazole; coated tablets.

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