SciELO - Scientific Electronic Library Online

 
vol.43 número2Validación de puntos críticos de la producción de SurfacenLiberación de la teofilina a partir de matrices hidrófilas que contienen algfinato de sodio procedentes de Sargassum cymosum (Phaeofphyta) índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista Cubana de Farmacia

versão On-line ISSN 1561-2988

Resumo

ARENCIBIA ARREBOLA, Daniel Francisco et al. Genotoxic assessment of D-004, extract from Roystonea regia fruit, by means of micronuclei assays. Rev Cubana Farm [online]. 2009, vol.43, n.2, pp. 0-0. ISSN 1561-2988.

D-004 is a lipid extract from the real palm fruit (Roystonea regia), which has demonstrated that is effective to prevent prostatic hyperplasia from testosterone and from phenylephrine in rats' experimental models. Aim of this paper was to determine if D-004 provoke changes in appearance frequency of micronuclei during oral administration of repeated doses for 8 weeks. Five experimental groups were created (7animals/group): a solvent control-group, three treated with D-004(500, 1 000, and 1 500 mg/kg), and a positive control-group treated with cyclophosphamide. There were no deaths or clinical signs of toxicity neither significant differences among controls and treated ones as regards the frequency of micronucleated polychromatophils erythrocytes, and the cytotoxic index. In conclusion, D-004 administered per os at doses used has neither clastogenic nor cytotoxic activity in bone marrow male OF-1mice in vivo.

Palavras-chave : D-004; micronuclei; prostatic hyperplasia; polychromatophils erythrocytes; OF-1 mice.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License