Resumo

ARENCIBIA ARREBOLA, Daniel Francisco et al. Effects of D-003, a mixture of aliphatic acids in a trial of in vivo chromosomal aberrations. Rev Cubana Farm [online]. 2010, vol.44, n.2, pp. 213-220. ISSN 1561-2988.

The D-003 is a mixture of high-molecular weight primary aliphatic acids purified from the sugar cane wax, whose main component is the octacosanic acid with antiosteoporotic, hypolipidemic and antioxidant effects. The aim of present paper was to determine if the oral treatment with D-003 for 14 days induces in vivo chromosomal aberrations in bone marrow of mice. Animals were randomized into 5 groups (5 mice/group/sex): one solvent control group, 3 D-003- treated with Ciclophosphamide (50 mg/kg), intraperitoneal route) 24 hours before sacrifice. D-003 neither increase the frequency of aberrations appearance (Structural or numerical) nor modified the mitotic index with regard to negative controls, whereas the cyclophosphamide increase both frequencies as expected. In conclusion, the D-003 has neither genotoxic potential nor cytotoxic on the bone marrow cells of NMRI mice.

Palavras-chave : Chromosomal aberrations; primary aliphatic acids; Ciclophosphamide; bone marrow; NMRI mice.

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