SciELO - Scientific Electronic Library Online

 
vol.44 número3Desarrollo tecnológico de un antiviral de amplio espectro para administración parenteral: ribavirina 100 mg/mLValidación del método analítico aplicable al estudio de estabilidad de risperidona solución oral 1 mg/mL índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista Cubana de Farmacia

versão On-line ISSN 1561-2988

Resumo

GARCIA PENA, Caridad Margarita et al. Performance assessment of dissolution assay method of 300 mg of Zidovudine tablets produced in Cuba. Rev Cubana Farm [online]. 2010, vol.44, n.3, pp. 297-305. ISSN 1561-2988.

A high-performance liquid chromatography method was validated to assess the dissolution of 300 mg Zidovudine tablets manufactured in Cuba with 265 nm ultraviolet (UV) detection. Filtration specificity, linearity, accuracy parameters were assessed. In influence filtration study it was shown that through the line-filter the active principle it isn't absorbed and without filtrate interferences thus it is recommended its use. It was possible to demonstrate the method specificity due to no interferences of the formula excipients in active principle assessment. Linearity curve was drawed in the interval of study concentrations with a correlation coefficient similar to 0.999. The method was precise since the values were within the established limits. Also, we made a statistical comparison of dissolution profiles of tablets manufactured in Cuba versus Retrovir® (leading drug) demonstrating that there is a similarity between the formulas release profile.

Palavras-chave : Zidovudine; validation; dissolution trial.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License