Resumo

NAPOLES LOPEZ, Raúl; RODRIGUEZ AMADO, Jesús Rafael; RODRIGUEZ ANTOMACHI, Maricel  e  LAFOURCADE PRADA, Ariadna. Validation of flavonoid quantification method in Passiflora incarnata L. tablets. Rev Cubana Farm [online]. 2014, vol.48, n.1, pp. 129-138. ISSN 0034-7515.

Introduction: to validate the flavonoid quantification method on Passiflora incarnata L. tablets by using quercetine as standard. Methods: selectivity, linearity, accuracy, precision and robustness were evaluated, using USP 30 and the regulations of the Center for the State Control of Drug Quality (CECMED). Results: under the conditions of this study, the method is selective, linear in a range of 60 to 140 % of flavonoid concentration. It showed accuracy and precision with global relative standard deviation of 0.67 %. The results did not significantly vary when the analytical conditions changed. Conclusions: under the established conditions, this method is reliable and allows obtaining appropriate results for the intended use.

Palavras-chave : validation; flavonoids; Passiflora incarnata L..

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