Resumo

DIAZ TORRES, Héctor Manuel; RUIBAL BRUNET, Ignacio  e  SANCHEZ RUIZ, Julieta. Fracaso del tratamiento antirretroviral y terapias de salvamento: Revisión actualizada. Rev cubana med [online]. 2003, vol.42, n.4, pp. 0-0. ISSN 1561-302X.

Those discoveries that are milestones in the search for an effective therapeutics against HIV/AIDS are stressed and it is reminded that an efficient vaccine has not been developed yet and that it has not been possible to attain the limited objective of turning that infection into a chronic and manageable condition at a large scale. The strategies of antiretroviral therapy, the definition and causes of the therapeutic failure, and the role of the HIV resistance to the antiretroviral agents as a cause of the failure of therapy are briefly reviewed. Reference is made to the results of the research on the prevalence of different mutations granting resistance in our country. The implications in relation to the antiretroviral therapeutics are also commented upon. The salvage therapies proposed at present are reviewed and their importance to face the challenges of medical assistance in patients with limited therapeutic options is assessed.

Palavras-chave : ACQUIRIED IMMUNODEFICIENCY SYNDROME; COMBINED MODALITY THERAPY [adverse effects]; AIDS VACCINES [adverse effects].