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Revista Cubana de Investigaciones Biomédicas
versão On-line ISSN 1561-3011
Resumo
BOFFILL CARDENAS, Maria de los Ángeles et al. Serum enzymatic activities of ceruloplasmin and myeloperoxidase in type 2 diabetics. Rev Cubana Invest Bioméd [online]. 2024, vol.43 Epub 10-Abr-2024. ISSN 1561-3011.
Introduction:
Type 2 diabetes mellitus is characterized by hyperglycemia due to insufficient insulin production by β cells. Myeloperoxidase promotes oxidative stress during inflammation and ceruloplasmin is considered its endogenous inhibitor.
Objective:
To evaluate the relationship between ceruloplasmin and myeloperoxidase, determined simultaneously in the serum of type 2 diabetic patients.
Methods:
A total of 362 type 2 diabetic patients and 110 healthy subjects were studied. Serum ceruloplasmin activity was determined by the Siotto KM method and myeloperoxidase by the Kraeisz JE method.
Results:
72% of diabetic patients had hyperglycemia and 77% had abdominal obesity. The activities of both enzymes were significantly increased relative to the control group. The correlation coefficient of enzyme activity was low. The ORMO/CP ratio of diabetic patients exceeded that of controls. Ceruloplasmin did not inhibit myeloperoxidase.
Conclusions:
Myeloperoxidase predominated, therefore, the inhibitory effect of ceruloplasmin was not manifested. The high activity of myeloperoxidase was associated with a worsening of the clinical picture of the diabetic patient.
Palavras-chave : serum enzyme activity; ceruloplasmin; myeloperoxidase; type 2 diabetes.