Introduction:

Non-invasive ventilation is a new modality of respiratory support therapy in patients with acute chronic obstructive pulmonary disease.

Objective:

To describe the factors related to failure of non-invasive ventilation treatment in the population of patients with exacerbated chronic obstructive pulmonary disease.

Methods:

An observational, descriptive and cross-sectional study was carried out in the intensive care units of Saturnino Lora Hospital, between January, 2011 and January, 2019.

Results:

The presence of leaks, the start time of the treatment longer than 24 hours, the decrease in the average values ​​of pH and Glasgow, the increase in respiratory and heart rates and PaCO2, are associated with failure of non-invasive ventilation.

Conclusions:

Alterations of typical clinical and hemogasometric variables of ventilation, structure the failure in this patients population.

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