Resumen

PEREZ ORTIZ, Letyer et al. Larga sobrevida en 5 pacientes con astrocitomas malignos. Rev Cubana Cir [online]. 2004, vol.43, n.1. ISSN 0034-7493.

Historically, the average time of survival of the patients with glioblastoma multiforme and anaplastic astrocytoma has ranged from 6 to 12 months and from 2 to 4 years, respectively. A few patients survive 5 years after surgery. The aim of this paper was to identify some common denominator in patients with long survival and confirmed histological diagnosis of anaplastic astrocytoma or multiform glioblastoma. Communication was established with the relatives of 67 patients operated on at the Institute of Neurology and Neurosurgery between 1983 and 1992. The age of the patients, the localization of the tumor, the neurological state at the onset of the disease, the time of evolution and the treatment used were analyzed. 5 patients had a time of survival over 7 years. The youngest patient was 35. The localization of the injury on the right frontal lobule, the clinical beginning without focal neurological defect, as well as the total exeresis was the norm in 80 % of these cases. The initial scoring over 70 in Karnofsky scale (KS) and the use of radiotherapy and chemotherapy after surgery was common to all of them. Young patients with highly malignant astrocytic gliomas located in the right frontal lobule that begin with a KS over 70 points and undergo total exeresis, postsurgery radiotherapy and chemotherapy have greater probabilities of prolonging their time of survival

Palabras clave : GLIOBLASTOMA; DISEASE-FREE SURVIVAL.