Revista Cubana de Cirugía
versión On-line ISSN 1561-2945
ROQUE GONZALEZ, Rosalba et al. Use of Tisuacryl® in esophagus anastomosis with other segments of the digestive tube. Rev Cubana Cir [online]. 2006, vol.45, n.2, pp. 0-0. ISSN 1561-2945.
The dehiscences and fistulae of esophagus anastomosis with pedicular segments of the digestive tube are frequent complications in esophagus surgery. In various recent national and foreign statistics, an incidence of even 40 % has been registered. This fact, together with the advantages reported on the use of synthetic adhesives like Tisuacryl® made us to take an interest in conducting a clinical study to extend the use of this product to reinforce the sutures in esophagus anastomosis with other segments of the digestive tube to prevent dehiscences. A prospective, controlled, randomized, multicentric, blind, phase II clinical assay was undertaken from January 1998 to February 2005. Patients admitted in “Calixto García” and “Miguel Enriquez” Hospitals with the diagnosis of esophageal diseases took part in the study. It was possible to introduce in our country a new application of Tisuacryl®, and it was proved that the use of the product is a much more advantageous choice than the conventional procedure only with suture, since it was obtained an effectiveness of 93 % in the experimental group compared to 64 % in the control group. Both groups were homogeneous as regards the control variables. Treatment with Tisuacryl® reduced the frequency of appearance of esophageal fistulae, and no adverse events were reported in relation to the use of this product.
Palabras llave : Tissue adhesive; Tisuacryl®; adverse event.