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Revista Cubana de Cirugía

versión impresa ISSN 0034-7493versión On-line ISSN 1561-2945


CASADEVALL GALAN, Inés et al. Conservative surgery and radical mastectomy in stage I and II breast cancer. Rev Cubana Cir [online]. 2008, vol.47, n.2. ISSN 0034-7493.

INTRODUCTION. Breast cancer is the first cause of death from cancer in females and it has become a pandemic threatening to continue if the way to prevent it is not found. The objective of this paper was to evaluate global survival and the disease free interval in patients that underwent conservative surgery plus radiotherapy and modified radical mastectomy as initial treatment, and to determine other prognostic variables, such as age, histological clinics, relapses and time elapsed between surgery and radiotherapy. METHODS. A retrospective and descriptive study was conducted in a group of patients with stage I and II primary breast cancer at «Julio Trigo López» Hospital from January 2000 to December 2005. Data were taken from the medical histories and surveys. A database was created and a descriptive analysis was made of the data, frequency and percentages for the case of qualitative and mean variables, and of the standard deviations for the quantitative variables. Survival and the disease free interval were estimated by Kaplan Meir's method and they were compared by curves according to the Sug Rank's variables of interest. The analysis of the prognostic variables of survival and disease free interval was carried out by Cox's regression analysis. RESULTS. The disease free interval was longer in conservative surgery than in the modified radical mastectomy. Global survival had a similar behaviour. Patients with positive Rh presented a longer disease free interval (88 %). The infiltrating carcinoma was the most frequent variety and it had the greatest number of relapses, which were influenced by the time elapsed between surgery and radiotherapy. The highest frequency of breast cancer was observed in females over 50. The therapeutic conduct of surgery plus radiotherapy and chemotherapy prevailed in conservative surgery, whereas chemotherapy predominated in the modified radical mastectomy. The locoregional relapses were more common in conservative surgery; however, the most frequent relapses in radical mastectomy were registered at a distance. CONCLUSIONS. The type of surgery did not exert a significant influence on the disease free interval, but there were differences among the conservative techniques. The prognostic factors size of the tumor, ganglionic state and hormone recipients influenced on the survival and on the disease free interval of all patients.

Palabras clave : Modified radical mastectomy; quadrantectomy; tumorectomy; global survival; disease free interval.

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