Resumen

PEREZ RUIZ, Andrés O et al. Biosíntesis de los productos del ácido araquidónico y su repercusión sobre la inflamación. Rev Cubana Estomatol [online]. 1998, vol.35, n.2, pp.56-61. ISSN 0034-7507.

The release of arachidonic acid or other unsaturated 20-carbon fatty acids, the icosatrienoic and icopentanoic acids, from hystic reserves is the first phase of the prostaglandins, thromboxines and leukotrienes synthesis. Once the arachidonic acid is released from thystic reserves, it is then turned into prostacyclines, prostaglandins and thromboxines through molecular oxygen cycling and addition catalyzed by cyclooxygenase present in the majority of cells. The lipoxygenases also metabolize the arachidonic acid into various products with hidroi-peroxi group in different positions and thus increase the leukotriene biosynthesis. The arachidonic acid metabolites resulted from both cycloxigenase and lipoxygenase action have a defined and important role in the various inflammatory process phases. Several pharmaceuticals assist in improving the inflammatory process by the inhibition of specific enzymes.

Palabras clave : ARACHIDONIC ACID [biosynthesis]; INFLAMMATION [metabolism].

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