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Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
Resumen
GUERRA ORDONEZ, Marta; PRIETO MIRANDA, Enrique; MELO, José Carlos y POMARES, Zoraima. Radiotratamiento de mafenida10 % Crema. Rev Cubana Farm [online]. 1996, vol.30, n.2, pp. 0-0. ISSN 1561-2988.
The application of ioninzing radiations with decontaminant ends is an alternative to guarantee the microbiological quality of many pharmaceuticals. The radiotreatment with mafenide 10 % cream, which did not meet the microbiological quality specifications established in the country, was carried out. The microbial charge was determined and a dosage study of the product was conducted, evaluating 3, 5, 7, and 10 KGy of gamma radiations with a Co60 radioisotopic source. Microbiological and chemicophysical evaluations were carried out before and after the treatment. It was decided to irradiate the product with 3 KGy as a minimum dose, in a continual way and in the "Product I" plant of the Food Industry Research Institute.
Palabras clave : MAFENIDE [radiation effects]; DRUG QUALITY; RADIOTHERAPY [standards]; RADIATION IONIZING; COPPER RADIOISOTOPES..