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Revista Cubana de Farmacia
Print version ISSN 0034-7515On-line version ISSN 1561-2988
Abstract
PEREZ BLANCO, María Elena and GARCIA VALDES, Jesús. Mejoramiento del proceso de obtención de citrato de piperacina. Rev Cubana Farm [online]. 1998, vol.32, n.2, pp.81-87. ISSN 0034-7515.
It is described the industrial procedure by which the piperazine citrate of pharmaceutical quality was obtained on making react at 60 oC an anhydrous piperazine solution with another solution of monohydrated citric acid. The mixed solution was subjected to a treatment with coal, filtration while hot, crystallization and purification. The adequate concentration for crystallization was determined, the concentration control was introduced by using the refractometric reading as a process control, and the charge used in the preparation of the lot when the mother liquids colleted in the previous lot were used was modified. The results of the accumulated yield were analyzed as the number of reproductions increased. Data obtained in the assays at the level of experimental production were included. It was concluded that the procedure is adequate for the obtention of piperazine citrate according to its economic and technical feasibility.
Keywords : PIPE RAZINES; DRUG INDUSTRY; CHEMISTRY; PHARMACEUTICAL; DRUG QUALITY; REFRACTOMETRY; CRYSTALLIZATION; DRUG STABILITY.