Abstract

BENITEZ LOPEZ, Ania; TILLAN CAPO, Juana  and  CABRERA GONZALEZ, Yolanda. Actividad analgésica y antipirética de un extracto fluido de Pimenta dioica L. y evaluación de su toxicidad aguda oral. Rev Cubana Farm [online]. 1998, vol.32, n.3, pp.198-203. ISSN 0034-7515.

The analgesic and antipyretic activity of the Pimenta dioica L. fluid extract was studied in experimental animals, as well as its acute oral toxicity. The analgesic effect was evaluated at doses of 825, 1 320 and 1 650 mg/kg by the technique of contorsions induced by chemical agents (Witkin et. al., 1961), whereas antipyresis was tested in rabbits at doses of 206 and 406 mg/kg against an endotoxin of E. coli. The results obtained in both studies were compared with ibuprofen 200 mg/kg, and it was proved that the oral administration of the extract at doses of 1 650 mg/kg -analgesia- and 406 mg/kg -antipyresis- has an efectivity similar to that of ibuprofen. The toxicological study was conducted in mice and it was obtained a DL50 of 2.56 g/kg, which allows to classify the extract as non toxic.

Keywords : ANTI-INFLAMATORY AGENTS; NON-STEROIDAL [administration & dosage]; PLANTS, MEDICINAL; PLANT EXTRACTS [toxicity].

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