Resumen

PERDOMO LOPEZ, Iliana et al. Evaluación de una zeolita natural modificada y decolorada como antimicrobiano. Rev Cubana Farm [online]. 1999, vol.33, n.3, pp.183-187. ISSN 0034-7515.

A methodology was developed to decolorize a natural zeolite modified by using orthophosporic acid 100 %. The product obtained was chemically controlled and no changes were observed in its structure as a result of decolorization, which was confirmed by determining its antimicrobial activity in vitro in the presence of grampositive and gramnegative microbial strains and of Candida albicans. It was proved that the minimum inhibitory concentration is 10 % for the active product. Suspensions were prepared with the raw material obtained for oral candidiasis with 0.6; 0.8 and 1.0 % of hydroxypropylmethyl cellulose as a suspension agent. According to the physical stability study, formulation B with 0.8 % of hydroxypropylmethyl cellulose presents the best results until the 60 days of study.

Palabras clave : ZEOLITES [chemistry]; DRUG EVALUATION.

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