Resumen

TARINAS REYES, Alicia; TAPANES PERAZA, Roland David  y  PEREZ AVILA, Lorenzo Jorge. Terapia antiviral para VIH-SIDA. Rev Cubana Farm [online]. 2000, vol.34, n.3, pp.207-220. ISSN 0034-7515.

During the last years many new antiviral agents have been incorporated to the chemotherapeutics. The pharmaceuticals established years ago as well as the new ones developed to treat HIV infected individuals are included in this review. The AZT was the first approved in March, 1987, followed by ddl (1991), ddc (1992), d4t (1994), and 3TC (1995). Later, the first protease inhibitor, saquinovir, was approved in December, 1995, followed by ritonavir (1996), indinavir (1996), and nelfinavir (1997); in addition to other inhibitors of the reverse transcriptase as neviparine (1996), delavirdine (1997), and efavirenz (1998), among others. At present new alternative therapies for this affection are being searched and developed. Some of the characteristics of these dugs, such as: action mechanisms (on which enzime each of them act and how they do it, viral cycle), dosage, incompatibilites and adverse reactions are dealt with in this paper.

Palabras clave : ANTIVIRAL AGENTS [drug therapy]; ACQUIRED IMMUNODEFICIENCY SYNDROME [pharmacolopgy]; DRUG THERAPY, COMBINATION.

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