Abstract

MARTINEZ MIRANDA, Lisette; LARA CASTRO, Maricela  and  TORRES GARCIA, Matilde. Estabilidad de tabletas de Rifampicina 300 mg. Rev Cubana Farm [online]. 2001, vol.35, n.1, pp.18-22. ISSN 0034-7515.

The stability study of rifampicin 300 mg was conducted. An analytical method developed and validated by high pressure liquid chromatography in reverse phase and ultraviolet detection was used for the quantification of the actives principle. The stability study of the tablets was conducted by the method of useful life and the accelerated method under isothermic conditions. There was no significant variation of the concentration during the time of study and, thus, the chemical and thermal stability of the active principle was proved. A period of 2 years was proposed as expiration date. A relative humidity of 75, 84 and 92% influenced on the stability of the formulation in the analyzed period.

Keywords : RIFAMPIN [pharmacokinetics]; DRUG STABILITY [methods]; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG QUALITY; CHEMISTRY, PHARMACEUTICAL [methods]; TECHNOLOGY, PHARMACEUTICAL; TABLETS [analysis].

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