Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
The stability study of rifampicin 300 mg was conducted. An analytical method developed and validated by high pressure liquid chromatography in reverse phase and ultraviolet detection was used for the quantification of the actives principle. The stability study of the tablets was conducted by the method of useful life and the accelerated method under isothermic conditions. There was no significant variation of the concentration during the time of study and, thus, the chemical and thermal stability of the active principle was proved. A period of 2 years was proposed as expiration date. A relative humidity of 75, 84 and 92% influenced on the stability of the formulation in the analyzed period.
Palabras llave : RIFAMPIN [pharmacokinetics]; DRUG STABILITY [methods]; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG QUALITY; CHEMISTRY, PHARMACEUTICAL [methods]; TECHNOLOGY, PHARMACEUTICAL; TABLETS [analysis].