Resumen

SORDO MARTINEZ, Liset; RODRIGUEZ DE LA ROSA, Ángel Rafael  y  CRUZ MORALES, Jorge. Validación de la técnica para la determinación cuantitativa de cefotaxima sódica por Clar. Rev Cubana Farm [online]. 2001, vol.35, n.2, pp. 104-108. ISSN 1561-2988.

The validation of the high-performance liquid chromatography method for the quantitative determination of cefotaxime sodium, a well-known antibacterial compound, was carried out. Taking into account that this method is rated as a method for quantitative determination of the active ingredient or main compound in formulations or raw materials, the following parameters were evaluated: specificity, linearity, precision and accuracy. The results showed that the technique is reliable since it allowed the determination of the studied compound in the face of synthesis impurities and degradation products. Also, the statistical processing of the results revealed the linearity, precision and accuracy of the method.

Palabras clave : CEFOTAXIME [analysis]; CEFOTAXIME [pharmacology]; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHEMISTRY PHAR-MACEUTICAL; TECHNOLOGY, PHARMACEUTICAL.

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