Abstract

DIAZ MOLINA, Milena; PEREZ SAAD, Héctor; SANCHEZ RODRIGUEZ, Nora  and  BU WONG, Margarita. Block of the audiogenic seizures and of the electroconvulsive shock by 2-phenyl-4, 4-bis-(hydroxymethyl)-2-oxazoline. Rev Cubana Farm [online]. 2004, vol.38, n.3, pp.1-1. ISSN 0034-7515.

Some aryl-oxazolines have been described as active substances on the central nervous system, with diverse effects and applications as depressants, anesthetics, anticonvulsants, etc. The purpose of the present paper is to study the possible effect of 2-phenyl-4,4-bis (hydroxymethyl)-2-oxazoline (OX) obtained by chemical synthesis under microwaves in 2 experimental models of epilepsy: the electroconvulsive shock by repetitive stimulation in mice and that of induction of convulsive seizures by audiogenic stimulus in gerbo mongol. The dose of 150 mg/kg of OX reduced the number of electric pulses, as well as its duration. This same dose blocked the seizures induced by audiogenic stimulus in gerbo and significantly reduced its severity (seizure degrees) and occurrence. These reults allow to assert that OX present an antiepilectic effect possibly related to an inhibition of glutamatergic synapse in the hippocampus.

Keywords : Anticonvulsant; audiogenic crisis; electroconvulsive shock; 2-oxazolines.