SciELO - Scientific Electronic Library Online

 
vol.39 número1Obtención de microesferas biodegradables de ácido poli L-láctico cargadas con doxorubicinaReformulación de tabletas de clorpromazina clorhidrato 25 mg índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

GARCIA DIAZ, Nuria; PADRON YAQUIS, Alejandro; MATEU, Liliana  y  ALBERTUS JIMENEZ, Ivonne. Development and validation of a methodology for cleaning areas of production of penicillamine tablets Development and validation of a methodology for cleaning areas of production of penicillamine tablets. Rev Cubana Farm [online]. 2005, vol.39, n.1, pp.1-1. ISSN 0034-7515.

A cleaning methodology was developed to be used in production and development areas, where work with penicillamine is done. It is a highly contaminating and toxic compound. A method was validated by high performance liquid chromatography that was selected due to the versatility of this type of techniques for detecting traces. The method proved to be specific, lineal, accurate and precise in the range of working concentrations. The limits of detection and quantification were determined. The sampling method by brushing was used and satisfactory results were attained. It was concluded that the cleaning procedures were effective for the worst of the settings

Palabras clave : Penicillamine; validation; cleaning validation.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons