Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
ALVAREZ CORREDERA, Mayra et al. Study of debrisoquine polymorphism in a sample of the Cuban population. Study of debrisoquine polymorphism in a sample of the Cuban population. Rev Cubana Farm [online]. 2005, vol.39, n.1, pp. 1-1. ISSN 1561-2988.
The differences in the capacity with which every individual metabolises a drug by a specific route has a clinical relevance for widely used drugs of a narrow safety range if that is the main route in the elimination of the drug, or if the number of therapeutic alternatives is limited; therefore, the pharmacogenetic information is essential in the personalized therapeutics and it contributes to a rational use of drugs. As the cytochrome P4502D6 (CYP2D6) catalyzes more than 65% of the commonly used drugs, the aim of this paper was to identify different CYP2D6 metabolising phenotypes in a sample of 104 subjects of the Cuban population by determining the metabolic ratio between urinary concentrations of debrisoquine and its metabolite 4OH-debrisoquine, quantified by high performance liquid chromatography. We found that 3.84% of the individuals studied were slow metabolisers.
Palabras llave : Genetic polymorphism; debrisoquine polymorphism; CYP2D6.