Resumen

BRITO PASCUAL, Idalmis; BETANCOURT RODRIGUEZ, Blas Yamir; VALENZUELA SILVA, Carmen  y  LOPEZ SAURA, Pedro. Experience with the adverse reactions associated with recombinant alpha 2b interferon in hematology. Rev Cubana Farm [online]. 2005, vol.39, n.2, pp. 1-1. ISSN 1561-2988.

Alpha 2b interferon is a cytokine with antiviral, antiproliferative and immunomodulator activity that has proved to be efficient for the treatment of viral and neoplastic diseases, This paper is aimed at describing the frequency of adverse reactions associated with the administration of alpha R Heberon (recombinant alpha 2b interferon) in hematological diseases. The basic characteristics of the patients, as well as the frequency, intensity and causality relation of the reported events  were analyzed. The most common adverse effects were the manifestations of the gripal syndrome that included fever, chills, astenia, myalgia, anorexia and headache. These manifestations are transitory and respond to the treatment with non-steroideal antiinflammatory drugs. Most of the events were from mild to moderate intensity and did not require the suspension of the treatment. To conclude, alpha R Heberon is a relatively safe drug for the treatment of hematological disorders.

Palabras clave : alpha 2b interferon; alpha R Heberon; adverse events; causality relation.

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