Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
BOTET GARCIA, Martha et al. Technological development and study of 0.1 % Idoxuridine (eyedrops). Rev Cubana Farm [online]. 2007, vol.41, n.2, pp. 0-0. ISSN 1561-2988.
Idoxyuridine just like the Thymidine, inhibits thymidyl-phophorylase and DNA-specific polymerases, needed for Thymidine incorporation in virus-DNA. Idoxyuridine, added to defective DNA, renders unfit virus to infect or destroys tissues or for its reproduction. Aim of present paper was achieve technological development of a Idoxyuridine-formulation administered by ocular route, which meet all quality criteria called for the product, e.g. organoleptic features, pH, assessment and sterility, a 2 years useful lifetime, temperature of 2-8 °C, and with its invariable physical, chemical and microbiologic features over stability study performed by means of accelerated stability study to 25 °C, and support-life of 2-8 °C during 6 months and 24 months, respectively.
Palabras llave : Idoxyuridine; formulation; stability.