SciELO - Scientific Electronic Library Online

 
vol.41 issue2Study on stability of Clonazepam tablets (2 mg) without lactoseDevelopment of a analytical method for quality control of 2 % Pilocarpine eyedrops author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista Cubana de Farmacia

Print version ISSN 0034-7515On-line version ISSN 1561-2988

Abstract

GARCIA PENA, Caridad M. et al. Analytical method by high resolution-liquid chromatography for assay of 2 mg Clonazepam tablets disolution without lactose. Rev Cubana Farm [online]. 2007, vol.41, n.2. ISSN 0034-7515.

A valid method was developed to assess 2 mg Clonazepam tablets disolution without lactose by high-performance liquid chromatography by UV detection to 254 nm. Establishment of Clonazepam in dissolution medium was confirmed, and parameters of specificity, linearity, and accuracy were assessed, as well as influence of filtration and stability or active principle. Linearity curve was drawed in rank of 1, 2-2,6 mg/mL, with a correlation coefficient similar to 0,99418; statistical test wasn’t statistically significant for interceptor and slope. In study, it was possible to demonstrate that stability or active principle in dissolution was maintained in more than double of duration of dissolution assay.

Keywords : Clonazepam; valaidation; dissolution assay.

        · abstract in Spanish     · text in Spanish

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License