Revista Cubana de Farmacia
versão On-line ISSN 1561-2988
DEL CAMPO PORTALES, Diamelva et al. Study of Cuban quitosana as agglutination agent. Rev Cubana Farm [online]. 2007, vol.41, n.2, pp. 0-0. ISSN 1561-2988.
To assess ability of Cuban quitosona as agglutination agent, derived from lobster quitine, we performed an experimental design of which he variable were: relationship between quitosana mass and granular base as well as lactic acid concentration in agglutination solution. Results shows that lactic acid percentage hasn’t influence on properties of granules processed using quitosana. Above mentioned relationship influences on average particle size of study granules. Properties of quitosana-processed granules, regardless of whether quitosana/granule base relationship and lactic acid percentage, have a intermediate behaviour between polyvinyl-pyrrolidone and gelatine. With model drug ,chloriquine sulfate, use of Cuban quitosana like agglutination agent, yields tablets with important properties. Also, we compared its effectiveness as agglutination agent regarding traditional excipients: gelatine, polyvinyl-pyrrolidone, and celacol, with propranolol chlorhydrate as model drug. Granules obtained shows that 1 % quitosana has a action similar to polyvinylpirrolidone, celacol, and gelatine, whereas in the case of tablets, regardless value of quitosana concentration, is similar to polyvinylpirrolidone.
Palavras-chave : Agglutination agent; Cuban quitosana; tablets; wet route..