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Revista Cubana de Farmacia

Print version ISSN 0034-7515On-line version ISSN 1561-2988

Abstract

SUAREZ PEREZ, Yania; GARCIA PULPEIRO, Oscar  and  CUETO LEON, Marisel. Useful life study of QL ointment . Rev Cubana Farm [online]. 2007, vol.41, n.3. ISSN 0034-7515.

QL ointment is a new drug under development stage used to treat the acute hemorrhoidal outbreak. To introduce it in the therapeutics,it is necessary to prove its physical and chemical stability. The useful life studies were conducted according to the current demands. To this end, 3 pilot batches, QL01, QL02 y QL03, stored at room temperature at controlled refrigeration and temperature, were analyzed. The studies were undertaken at 0, 1, 2, 3, 6, and 12 months. No changes were observed neither in the organoleptic properties, nor in the extensibility area. The pseudoplastic tixotropic flow characteristic of this type of system was maintained at 6 months. The active principles chitin and lidocaine chlorhydrate were steady in time for all the storing conditions evaluated

Keywords : Rectal ointment; stability; chitin; lidocaine chlorhydrate.

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