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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

SUAREZ PEREZ, Yania; GARCIA PULPEIRO, Oscar  y  CUETO LEON, Marisel. Useful life study of QL ointment . Rev Cubana Farm [online]. 2007, vol.41, n.3. ISSN 0034-7515.

QL ointment is a new drug under development stage used to treat the acute hemorrhoidal outbreak. To introduce it in the therapeutics,it is necessary to prove its physical and chemical stability. The useful life studies were conducted according to the current demands. To this end, 3 pilot batches, QL01, QL02 y QL03, stored at room temperature at controlled refrigeration and temperature, were analyzed. The studies were undertaken at 0, 1, 2, 3, 6, and 12 months. No changes were observed neither in the organoleptic properties, nor in the extensibility area. The pseudoplastic tixotropic flow characteristic of this type of system was maintained at 6 months. The active principles chitin and lidocaine chlorhydrate were steady in time for all the storing conditions evaluated

Palabras clave : Rectal ointment; stability; chitin; lidocaine chlorhydrate.

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