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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

GARCIA PENA, Caridad M et al. Validation of the dissolution assay of propylthiouracil 50 mg. Rev Cubana Farm [online]. 2008, vol.42, n.1. ISSN 0034-7515.

A method to evaluate the dissolution of propylthiouracil tablets 50 mg by spectrophotometry, with ultraviolet detection of 274 nm, was validated. Specificity, linearity, precision and filtration influence were the evaluated parameters. The linearity curve was made at the range from 3.32 to 7.75 µg/mL with a correlation coefficient equal to 0.99984. The statistical test for the interval and the slope was not significant. In the study of filtration influence it was proved that the active principle was not absorbed in the filtration and that there were no interferences in the filtration, which made its use possible

Palabras clave : Propylthiouracil validation; dissolution assay.

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