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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

HERNANDEZ GARCES, Héctor Rubén; PINOL JIMENEZ, Felipe  y  PANIAGUA ESTEVEZ, Manuel. Treatment in patients operated on of the stomach with elevated biliary acids and positive Helicobacter pylori. Rev Cubana Farm [online]. 2008, vol.42, n.1. ISSN 0034-7515.

A non-blind randomized experimental study was undertaken. It included 30 adults of both sexes with diagnosis of alkaline chronic gastritis due to duodenogastric reflux, in stomach resections (Billroth I, Billroth II), by upper endoscopy, with elevated total biliary acids and positive Helicobacter pylori. These patients were divided into 2 groups of treatment during 8 weeks. The group A was composed of 15 patients and received treatment with colloidal bismuth subcitrate (Q-ulcer), metronidazole and tetracycline, plus ranitidine as H2 antihistaminic. The group B was made up of 15 patients and it was administered microcrystalline cellulose (Microcel). Metoclopramide was given to both groups as a prokinetic drug during the whole treatment. The indexes for the eradication of H. pylori infection were 46.7 % for group A, and 42.9 % for group B. The concentration of total biliary acids at the end of the treatment decreased in 53.3 % of the patients from group A and in 71.4 % in group B. The concentration of total biliary acids in the gastric residue at the end of the treatment did not influence on the clinical, endoscopic and histological evaluation of the patients in both treatment schemes. No adverse secondary effects were observed in the patients from group A. One patient (6.6 %) from group B left the study because its clinical picture got worse. He underwent surgery and it was considered a failure of the treatment. It was concluded that these therapeutic schemes were not efficient

Palabras clave : Operated stomach; duodenogastric reflux; Helicobacter pylori.

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