Resumen

SUAREZ PEREZ, Yania; GARCIA PULPEIRO, Oscar  y  CUETO LEON, Marisel. Accelerated stability of QL ointment. Rev Cubana Farm [online]. 2008, vol.42, n.1. ISSN 0034-7515.

QL ointment is a rectal ointment under development stage devoted to the treatment of rectal affections. The combination for the first time of quitine and lydocaine chloride in a semisolid product of oleaginous base requires the study of the stability behaviour. To obtain information on its stability, a study was carried out under the established conditions. 3 pilot batches QL01, QL02 and QL03, stored at a temperature of 40 2 C, were analyzed. The studies were conducted at 0, 1, 2, 3 and 6 months. No changes were observed neither in the organoleptic properties, nor in the sedimentation stability and the extensibility area. The pseudoplastic thixotropic flow characteristic of this type of system was maintained after 6 months. The active principles were stable under the assayed conditions

Palabras clave : Rectal ointment; stability; quitine; lydocaine chloride.