Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
DEL BARRIO ALONSO, Gloria; ALVAREZ RODRIGUEZ, Ángel L.; VALDES GARCIA, Suria M. y PARRA FERNANDEZ, Francisco. Methodology for the preclinical screening of anti-herpesvirus activity starting from natural products . Rev Cubana Farm [online]. 2008, vol.42, n.2, pp. 0-0. ISSN 1561-2988.
Herpesviridae is one of the viral families of greatest impact on human and animal health. HSVs are the etiological agents of very common infections associated with a broad range of clinical symptoms. The latent nature of the infection allows the virus to escape from immune responses, hindering the obtention of efficient anti-herpes vaccines. This fact has encouraged scientists to search new anti-herpes drugs, and that's why the establishment of a rapid methodology for the in vitro evaluation of new products with potential antiviral activity is urgently needed. In this work, we describe the complete guide followed by the Antiviral Natural Products Research Group (Faculty of Biology, University of Havana) to perform the screening for antiviral activities among natural products. This guide includes the preliminary evaluation assay and a variety of secondary tests.
Palabras llave : Antiviral; anti-herpes; virucide; natural products.