Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
TACORONTE MORALES, Juan E. et al. Cannabinoids: analogues and therapeutical perspectivas II. Rev Cubana Farm [online]. 2008, vol.42, n.3, pp. 0-0. ISSN 1561-2988.
At present, a great amount of valuable information and experimental data has been generated that correlate Cannabis sativa and its secondary metabolites with medicine (therapeutic treatment), pharmacology (experimental animal models) and synthetic chemistry (design and generation of new structures and biososteric analogues), showing the importance of the study about this plant, its extracts, metabolite precursors and natural and synthetic analogues as therapeutic agents. Taking theses points into consideration, this article reviews the therapeutic implications of cannabinoid systems (endogenous, natural, and synthetic) on several pathologies of central nervous system, including: cannabinoid type concepts, cannabinoid receptor systems CB1 and CB2 and preclinical studies devoted to therapeutic effects of the cannabinoids since 1970 until 2006
Palabras llave : Cannabis; cannabinoids; therapeutic potential; ligands; activity.