Abstract

ESPINO HERNANDEZ, María; MARTINEZ MOTAS, Isabel; COUTO RAMOS, María Julia  and  ZUAZO SILVA, Jorge L. Effectiveness of a combined antimicrobial treatment by means of the draughtboard. In vitro and in vivo assessment. Rev Cubana Farm [online]. 2009, vol.43, n.2. ISSN 0034-7515.

The aim of present paper was to evaluate clinical effectiveness of combined antimicrobial treatment by means of in vitro synergism tests and to determine effectiveness of used procedure to direct applications of these treatment strategies in patient presenting with sepsis from varied resistance bacteria. Treatment applied was assessed in 163 newborn patients presenting with sepsis from positive hemoculture in "America Arias" University Gynecology-Obstetrics Hospital from January 1993 to December 2000, by checkerboard method in microtritate plates. In vitro synergic drug combinations showed a high probability of clinical effectiveness, independently of susceptibility pattern of microorganism event versus resistant strains to both antimicrobials used in treatment. All in vitro antagonistic results correspond both with a therapeutic clinical failure. Procedure used may be a valuable tool to direct therapeutics in patients presenting with sepsis from resistant microorganisms.

Keywords : Pharmacologic synergism; drugs antagonism; combined therapy; antimicrobials.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )