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Revista Cubana de Farmacia
versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988
Resumen
ARENCIBIA ARREBOLA, Daniel Francisco et al. Genotoxic assessment of D-004, extract from Roystonea regia fruit, by means of micronuclei assays. Rev Cubana Farm [online]. 2009, vol.43, n.2. ISSN 0034-7515.
D-004 is a lipid extract from the real palm fruit (Roystonea regia), which has demonstrated that is effective to prevent prostatic hyperplasia from testosterone and from phenylephrine in rats' experimental models. Aim of this paper was to determine if D-004 provoke changes in appearance frequency of micronuclei during oral administration of repeated doses for 8 weeks. Five experimental groups were created (7animals/group): a solvent control-group, three treated with D-004(500, 1 000, and 1 500 mg/kg), and a positive control-group treated with cyclophosphamide. There were no deaths or clinical signs of toxicity neither significant differences among controls and treated ones as regards the frequency of micronucleated polychromatophils erythrocytes, and the cytotoxic index. In conclusion, D-004 administered per os at doses used has neither clastogenic nor cytotoxic activity in bone marrow male OF-1mice in vivo.
Palabras clave : D-004; micronuclei; prostatic hyperplasia; polychromatophils erythrocytes; OF-1 mice.