Abstract

ANDREAZZA, Itamar Francisco; MAAS, Martha Maria; PESSATTI, Marcos Luiz  and  BELLE BRESOLIN, Tania Mari. Liberación de la teofilina a partir de matrices hidrófilas que contienen algfinato de sodio procedentes de Sargassum cymosum (Phaeofphyta). Rev Cubana Farm [online]. 2009, vol.43, n.2. ISSN 0034-7515.

The sodium alginate extracted from seasonal Sargassum cymosum samples (autumn, winter, spring and summer) in Paciência Beach (Penha- SC-Brazil) showed a viscosity of 18.3, 33.5, 62.6 and 34.2 mPa·s, respectively. Theophylline tablets(60 mg) containing 35 % of sodium alginate samples were analyzed by dissolution profile in a dissolution device at 100 rev×min^-1 and 37 °C, using water as dissolution medium, during 6 h. Tablets with the lesser viscous sodium alginate sample (autumn) showed a complete disintegration and drug release after 1 h. Despite all others tablets have exhibited the same drug release mechanism, by diffusion, the winter sodium alginate tablets released > 90 % of theophylline after 3 h, while spring and summer sodium alginate tablets showed similar dissolution profile with a release > 90 % of drug after 6 h. In general, the less viscous polymers showed a faster drug release, but probably other characteristics beside viscosity have played role in this process.

Keywords : Sodium alginate; hydrophilic matrix; theophylline; drug release.

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