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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

BILBAO DIAZ, Miguel Francisco et al. Inferable analysis related to promotion of the absorption potentialities from 1-O-alkyl glycerol family. Rev Cubana Farm [online]. 2009, vol.43, n.3. ISSN 0034-7515.

The interrelation among the physical-chemical properties and the bioavailability of a 1-O-alkyl glycerol family is discussed. As reference compounds we used molecules presenting a structural-functional similarity with these compounds, which have been recognized as class I high quality promoting agents. TOPS-MODE approach (ModesLab) was used to estimate spectral moments with different weighing as descriptors of the more relevant physical-chemical properties used in the achieved predictive models of intestinal permeability, and its interpretation in terms of contribution of 1-O-alkyl glycerols functional groups of. From this analysis we established inferred interpretations on the theoretical potentials of this family for its prospective evaluation as promoting agents of class I absorption. This computer-assisted in silico screening approach allowed us to call for that 1-O-alkin glycerols, particularly in the 1-O-hexadecyl glycerol, and 1-O-octadecil glycerol, are excellent candidates to demonstrate its high promotion capacity according to in vivo studies, which have gained percentage high levels of bioavailability (> 90 ). We conclude that according a discriminating analysis, all family members had potentials for gastrointestinal absorption.

Palabras clave : 1-O-alkyl glycerol; absorption promoters; bioavailability.

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