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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

ARRUZAZABALA VALMANA, Lourdes et al. Efecto de D-004, un extracto lipídico extraído de las frutas de la palma real (Roystonea regia) sobre las contracciones provocadas por la Fenilefrina sobre la próstata aislada de rata. Rev Cubana Farm [online]. 2009, vol.43, n.3. ISSN 0034-7515.

D-004, a lipid extract of Roystonea regia fruits, inhibits norepinephrine-elicited contraction in rat vas deferens. Nevertheless, the effect of D-004 on a1-adrenergic contractile responses in isolated prostate preparations had not been studied. Therefore, this study investigated the effects of D-004 on phenylephrine-induced contractions in isolated rat prostate strips. D-004 (125-500 mg/mL) was added to prostate preparations in which contractions were induced with phenylephrine (10-6-10-4 M) or with ClK (50 mM). D-004 (250-500 mg/mL) significantly (p < 0,01).and dose-dependently inhibited the phenylephrine-induced contractions through a non-competitive mechanism, since it reduced (12-60 %) the maximal contraction to phenyle phrine with respect to control preparations. D-004 at 500 mg/mL inhibited similarly both ClK and phenylephrine-contractile responses. Tamsulosin (0.01 mg/mL) abolished (100 % inhibition) the phenylephrine, but unaffected the ClK-induced contractions.

Palabras clave : D-004, isolated prostate; benign prostate hyperplasia; phenylephrine; Roystonea regia.

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