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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988


GUTIERREZ MARTINEZ, Ariadne; GAMEZ MENENDEZ, Rafael; PARDO ACOSTA, Balia  y  MARRERO COFINO, Gisela. Estrus cycle length in Sprague Dawley rats in uterus using Roystonea regia extract. Rev Cubana Farm [online]. 2009, vol.43, n.3. ISSN 0034-7515.

D-004 is a mix of fatty acids inhibiting significantly Testosterone- induced prostatic hyperplasia in rodents. The aim of present paper was to demonstrate the potential side effects on estrus cycle of F1 female rats exposed in uterus to D-004. We used Sprague Dawley rats, distributed randomly in 4 groups: a control one and another three treated with D-004 at a dosage of 500, 750 and 1 000 mg/kg; in the female rats we administered the dose by mouth from the 15 days before mating, and up to breast feeding termination. In each female rat by litter of F1 generation, the vaginal cytology was studied, and we estimated the approximate length of cycle, remained un-affected since there were not significant differences (p= 0,1537) among treatment groups and the control one. These results show that D-004 fails to reveals alterations in the estrum cycle of female litters exposed in uterus.

Palabras clave : D-004; fatty acids; rats; estrum cycle.

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