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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

GARCIA PENA, Caridad Margarita et al. Analytical methods validation of processes control in injectable antitumor agents. Rev Cubana Farm [online]. 2010, vol.44, n.1, pp.13-20. ISSN 0034-7515.

Alternative analytical methods were validated for the process control of 500 mg florouacil, 50 mg doxorrubicin and 50 mg methotrexate by spectrophotometry because of they are more simple and economic allowint to control the drugs quality in process anaslysis control. Calibration curves of fluorouracil, doxorrubicin and methotrexate were plotted in interval from 60 to 140 %, where there were linear with correlation coeficients similar to 0.9998, 0.9999 and 0.9999, respectively; statistical text for intercept and slope were considered as non-significant. Recoveries of 99.97, 99.98 and 99.35 % were achieved, respectively in study concentration interval and Cochran and t-Student tests were also non-significant. Methods were specific, linear, precises and exacts in interval of study concentrations.

Palabras clave : Spectrophotometry; doxorrubicin; methotrexate; fluorouracil; injectable.

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