Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
CARBAJAL QUINTANA, Daisy et al. Effect of D-004, a fruit extact from Roystonea regia and Omega-3 in a model of forced swimming in mice. Rev Cubana Farm [online]. 2010, vol.44, n.1, pp. 79-86. ISSN 1561-2988.
Depression is among the major causes of morbidity and mortality of adult population and its pharmacologic management includes among other alternative options, the use of the complementary medicine, e.g. the fish oil rich in Omega-3 fatty acids (AGw3). The D-004, a lipid extract of Real Palm fruits (Roystonea regia) consisting of a fatty acid mixture, has a moderate antidepressant action. The aim of present paper was to compare the effects of oral treatment using D-004 with the AGw3 and with its combined therapy in forces swimming in mice. Thus, the male mice were distributed into 8 groups: one as control treated with vehicle, two with D-004 (250 and 500 mg.kg), two with AGw3 (250 and 500 mg/kg), two with the combination, and another with imipramine (10 mg/kg i.p.). All treatments decreased significantly the immobility time regarding the control, without differences among similar dose of respective treatments. We conclude that D-004, the AGw3 and its combined therapy were similary effective to reduce the immobility time in mices without additive or synergic effects with the combined administration of both substances.
Palabras llave : D-004; Omega-3 fatty acids; Roystonea regia; depression; forced swimming.