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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988

Resumen

FERNANDEZ DORTA, Lilia; MAS FERREIRO, Rosa; FERNANDEZ TRAVIESO, Julio César  y  HERNANDEZ ORTEGA, Caridad. Effect of purified alcohols extract from the bee wax (Apis mellifera) in two analgesia models. Rev Cubana Farm [online]. 2010, vol.44, n.2, pp.205-212. ISSN 0034-7515.

The D-002 is a mixture of 6 high molecular weight aliphatic acids purified from bee wax (Apis mellifera). The aim of present study was to research the effects of an oral treatment using D-002 on the acetic acid- induced abdominal writhings and in the hot plate model in mice. Animals were randomized distributed to 5 groups (10-20 animals/group): a control one received the Gum Arabic vehicle/H20, three received D-002 (25, 125 and 250 mg/kg), and another received aspirin (abdominal contortions model) or morphine (hot plate). The D-002 inhibited the above mentioned writhings in a 44., 44,8 and 47. , respectively; however, not modified the response latency in the hot plate model. These results demonstrate that the D-002 (25-250 mg/kg) oral treatment may to inhibit in a moderate way the above mentioned writhings without to affect the response to hot plate. It suggests that the D-002 exerts a peripheral analgesic action but not a central level.

Palabras clave : Acetic acid; abdominal writhings; hot plate; analgesic; Apis mellifera.

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