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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988


LOURIDO PEREZ, Hetzel de la C.  y  MARTINEZ SANCHEZ, Gregorio. The Bixa orellana L. in treatment of stomatology affections: a subject that hasn't studied yet. Rev Cubana Farm [online]. 2010, vol.44, n.2, pp.231-244. ISSN 0034-7515.

From the Bixa orellana L. (bija) tropical plant seeds a pigment (annatto) was extracted which is basically composed by carotenoids (bixine/nor-bixine). Due to its resistance to chemical agent's action but not to sun effects, it is used preferably to food and drinks coloring. Daily dose allowance recommended by HWO is of 0-0.065 mg/kg/bw. Annate is a coloring agent with a very low toxicity for humans, even when some low rates of allergic events have been reported. Annate extracts have different pharmacological properties including the antitumor, anti-inflammatory, astringent, emollient, antiseptic, antibacterial, antioxidant, cicatrizant among others and has been prescribed in wounds and burns cure. Considering that in the therapeutical array available for stomatologist the cicatrizant antioxidant, anti-inflammatory and antimicrobial local actions are limited and by no means a product fulfilling all these properties together, we made a bibliographic updating of Bixa orellana L. subject related to its chemical, toxicology composition and interesting pharmacological effects for potential treatment of stomatology disorders. There are evidences on usefulness of these extracts for stomatology disorders, but these must to be still validated from the clinical point of view with trials performed according to the good clinical practices before any application in Cuban stomatology services.

Palabras clave : Bixa orellana L.; Bixine; norbixine; annate; stomatology.

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