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Revista Cubana de Farmacia

versión impresa ISSN 0034-7515versión On-line ISSN 1561-2988


DELGADO-ROCHE, Livan  y  MARTINEZ-SANCHEZ, Gregorio. New approaches on the function of plasmatic lipoproteins in diseases of atherothombosis origin. Rev Cubana Farm [online]. 2010, vol.44, n.2, pp.245-258. ISSN 0034-7515.

Atherosclerosis and its inherent complications are one of the more frequent death causes in western world because it is a chronic and progressive disease, which provokes many damages to blood vessels wall. These damages promote the formation of atheromatous and fibrotic plaques, which are thickened regions of the intima of arteries and are formed by fibrotic tissue, plasma and immunocompetent cells, as well as by lipids. Cholesterol of low-density lipoproteins and the oxidative modification of these particles are the center of the hypotheses formulated around the atherogenesis. While, its biological counterpart, the high-density lipoproteins have been classified as antiatherogenous and has been assumed that its decrease is a cardiovascular risk factor, however, recently, has been possible to prove that these criteria aren't absolutes. The clinical trials performed have demonstrated that beneficial effects of cholesterol of high-density lipoproteins depend mainly on its quality and not on its quantity. In present paper are showed new reasons on the function of theses molecules in atherosclerosis.

Palabras clave : Atherosclerosis; cardiovascular risk factors; high-density lipoproteins; low-density lipoproteins; oxidative stress; inflammation.

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