Abstract

FERNANDEZ HERNANDEZ, Nubia; MARTINEZ SANCHEZ, IGregorio  and  CEDENO PALENZUELA, Manuel Enrique. Function of hydrogen peroxide in cases of vitiligo. Rev Cubana Farm [online]. 2010, vol.44, n.3, pp.390-402. ISSN 0034-7515.

Vitiligo is a pigmentation disorder with an incidence between the 0.5 and the 3 % at worldwide. It is characterized by a skin depigmentation provoked by presence of dysfunctional melanocytes in epidermis. When oxidative stress triggering events are present, hydrogen peroxide concentrations clearly increase in the melanocytes and keratinocytes. The keratinocytes act as a source of oxygen and transfer to melanocytes high amounts of hydrogen peroxide. Experimental evidences have demonstrated that due to the high hydrogen peroxide concentrations in epidermis of vitiligo patients affecting the concentrations of butyryl-cholinesterase and the acetylcholinesterase, the enzymatic activity in 6HB4 cycle, propiomelanocortins and stress protein among many events. All these events after a hasty situation on a genetically predisposing subject could to promote changes in skin pigmentation that as a last resort leading to vitiligo.

Keywords : Hydrogen peroxide; vitiligo; oxidative stress.

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