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Revista Cubana de Farmacia

Print version ISSN 0034-7515On-line version ISSN 1561-2988


LOPEZ HERNANDEZ, Orestes Darío et al. Microencapsulation of Tramadol in polyactic acid by aspersion drying. Rev Cubana Farm [online]. 2010, vol.44, n.4, pp.432-442. ISSN 0034-7515.

An interesting subject for pharmaceutical industry is the search of technologies to achieve pharmaceutical ways for administration and transportation of cytostatics, anti-inflammatories, peptides and hormones among other drugs implicating a reduction of its toxicity or a contolled releasing of active principle to increase its effectiveness. In present paper authors studied the influence of fluid flow in feeding, of atomization air and of driying; different physicochemical and morphological features (size, shape, porosity and distribution in the particles size, and the effectiveness of active principle encapsulation) of Tramadol's microspheres. As result, it was possible to achieve microspheres of 18.93 ± 2.31 µm with an spherical shape, a non-porous surface demostrating it by X-ray difractometry and Tramadol encapsulation in the polymer.

Keywords : Tramadol; aspersion driying; microencapsulation.

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