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Revista Cubana de Farmacia

Print version ISSN 0034-7515On-line version ISSN 1561-2988


LOPERA CARDONA, Seneida  and  GALLARDO CABRERA, Cecilia. Study of photodegradation of folic acid encapsulated in microspheres of gum arabic and maltdextrin. Rev Cubana Farm [online]. 2010, vol.44, n.4, pp.443-455. ISSN 0034-7515.

In present paper a par ionic HPLC method was adapted to measure in a selective way the folic acid and its two degradation products formed under the irradiation conditions used (250 Wm2). The retention times were: folic acid (10.2 min; formylpterin (4,4 min) and p-aminobenzoil-glutamic acid (6,1 min). Method was applied to determine the wavelength accounting for photodegradation and also to quantify the degradation percentage suffering ty the folic acid added in microspheres obtained by aspersion driying and with different ratios of gum arabic and maltodextrin: 100-0, 80-20, 70-30 and 50-50 as covering materials. The responsible of photodegradation was the 350 nm radiacion and the microspheres with a great content of gum arabic had the greater ability to protect the folic acid, in these ones el degradation percentage was of 20.1 % whereas in the control it was of 49.2 %.

Keywords : Folic acid; photostability; HPLC method as stability indicator.

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