Revista Cubana de Farmacia
versión On-line ISSN 1561-2988
MALLOK, Akel; FLORES-SANCHEZ, Rosa María; ALONSO-RODRIGUEZ, Celia Ángela y MARTINEZ-SANCHEZ, Gregorio. Lack of Redox balance in male sterility. Rev Cubana Farm [online]. 2011, vol.45, n.2, pp. 283-296. ISSN 1561-2988.
The male sterility is considered as one of the factors more contributing to couple sterility. Join to conventional factors originate it condition it was possible to identify a cause with a high level of repercussion: the oxidative stress, which is the result of the imbalance between generation of reactive oxygen species and the antioxidants that may to cause damages or deformities in the spermatozoa and eventually male sterility. The reactive oxygen species are produced due to different mechanisms present in semen, motionless spermatozoa or with motility disorders, leukocytes and morphologically normal spermatozoa but functionally abnormal. Among these damages it is present the lipid peroxidation to spermatic membrane and the nuclear and mitochondrial DNA fragmentation. The damages of oxidative stress on DNA may also to cause disorders in offspring including cancer and achondroplasia. Lipid peroxidation leads to an alteration in the membrane affecting its structure and function. The human spermatozoon membrane contains a high proportion of poly-non-saturated fatty acids therefore its oversensitivity to lipid peroxidation is very high. The reactive oxygen species have different effects on spermatic cells, being a very controversial topic. The aim of present paper was to update readers on some of the biochemical features related to the production of reactive oxygen species and the diagnostic methods used to detect the human sterility.
Palabras llave : Male sterility; oxidative stress; semen; male reproductive system.